The Large Cybertooth is a beast encountered in the final level of N.O.V.A. 2 (Inner Hell). It is a much larger version of a Cybertooth and can kill Kal (the player) in 2 hits. There is a similar one encountered in N.O.V.A. 3, though much smaller in comparison to this one.
The best weapons against the large cybertooth are the Rocket Launcher, Plasma Rifle or the Alien Lightning Gun. An effective strategy for taking it down is to paralyze it when it is about to pounce on you, and fire the plasma rifle at it while running away. Never let it back you into a corner or it will beat you for sure. If you use the Rocket Launcher against it slow time when you reload so you have more time to evade its attacks.